gene product
[대역어] None
[용어속성] Term
[용어속성] Term
mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses
Research
[키워드] activate
analysis
cardiovascular disease
catalytic
Coagulopathy
expression
gene product
IL-1β
IL-6
immune cell type
Inflammatory
Inflammatory response
limit
LPS
mechanism
metabolism
monocyte
Monocytes
mTOR inhibitor
NAD+
pathway
polyfunctional responses
primary human monocyte
pro-inflammatory
pro-inflammatory cytokine
procoagulant
Regulation
response
risk
Support
tested
tissue
TLR4
transcriptional activity
transcriptional response
Treatment
with HIV
[DOI] 10.1038/s42003-022-03804-z [Article Type] Research
[DOI] 10.1038/s42003-022-03804-z [Article Type] Research
Relevance between COVID-19 and host genetics of immune response
Review article
[키워드] 2019-nCoV
ACE2
ACEAngiotensin Converting Enzyme
Activation
acute respiratory syndrome
Affect
allele frequency
Alter
alveolar
angiotensin
angiotensin converting enzyme
Antigen presentation
antigenic
antigenic peptide
association
binding
caused
CD4+
CD8+
cellular immunity
change
changes in
China
complications
coronavirus disease
COVID-19
cytokine secretion
death
disease
Endoplasmic reticulum
expressed
expression
expression data
expression level
Gas exchange
gene product
Genes
Genetic
Genotype
HBVHepatitis B virus
HCVHepatitis C virus
Hepatitis B virus
hepatitis C virus
high mortality
highlight
HIVhuman immunodeficiency virus
HLA
HLA class I
HLA gene
HLAHuman leukocyte antigen
host genetics
Human immunodeficiency virus
human leukocyte antigen
immune
immune response
impair
Infection
Lungs
MHC class I
Non-small cell lung carcinoma
NSCLCNon-small cell lung carcinoma
outbreak
pathogen
Pathogenesis
peptide
phenotype
pneumocyte
Pneumocytes
polymorphism
populations
precursor
present antigen
progression
RASRenin-angiotensin system
Relevance
renin-angiotensin system
reported
responsible
resulting
SARS-CoV
SARS-CoV-2
SARS-COV-2 infection
SARSSevere Acute Respiratory Syndrome
Severe acute respiratory syndrome
severe hypoxia
Single nucleotide polymorphism
SNPSingle nucleotide polymorphism
Spread
susceptibility
T lymphocytes
T-cell responses
T-cells
variant
Variation
viral entry
viral infection
virus
virus spike protein
viruses
Wuhan
[DOI] 10.1016/j.sjbs.2021.07.037 [Article Type] Review article
[DOI] 10.1016/j.sjbs.2021.07.037 [Article Type] Review article
Addressing the ‘hypoxia paradox’ in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues
Review
[키워드] Abstract
accumulating
addressed
affected
analogue
analogues
candidate
caused
clinical evidence
clinical trial
consequence
COVID-19
COVID-19 patient
Critical care
Darbepoetin
deficiency
detrimental
dimension
double-blind
downstream
Effect
EPO
expected
gene product
host responses
hypoxia
IMPROVE
increasingly
Inflammation
Intensive
kidney
literature review
lung
male
Manifestations
microRNA
Mortality
multiple organ failure
neuroprotection
Neuropsychiatric
outbreak
outcome
overcome
pandemic
Patient
physiological
placebo-controlled
predicted
Prognosis
randomized clinical trial
receive
recent
Recombinant human EPO
Research
SARS-CoV-2
serum
severe COVID-19
Signaling
Spread
subject
Substitution
suggested
Support
treated
Treatment
[DOI] 10.1186/s10020-021-00381-5 PMC 바로가기 [Article Type] Review
[DOI] 10.1186/s10020-021-00381-5 PMC 바로가기 [Article Type] Review
The emerging role of perivascular cells (pericytes) in viral pathogenesis
Reviews
[키워드] AIDS
Angiogenesis
antigen-presenting cell
APCS
blood-brain barrier
cardiovascular system
caused
Cell
cognitive
complex
coronavirus
coronavirus disease
COVID-19
dengue haemorrhage
dengue virus
developmental
direct infection
disorder
dissemination
dysregulation
Endothelial cell
endothelial cells
facilitate
facilitated
gene product
HCMV
HIV/AIDS
Human
Human Cytomegalovirus
Human immunodeficiency virus
immunodeficiency
in viral
include
Inflammatory
Interaction
Japanese encephalitis
Major
modulation
neurological
organ
outcome
Pandemics
paracrine
Pathogenesis
pathogenic mechanism
Pathogens
penetration
pericyte
pericytes
perivascular
Placenta
retrovirus
SARS-CoV-2
secreted
Symptom
syndrome
the disease
therapy
Transmission
Vascular
vascular leakage
viral disease
viral pathogenesis
virus
virus
Zika virus
ZIKV
[DOI] 10.1099/jgv.0.001634 PMC 바로가기 [Article Type] Reviews
[DOI] 10.1099/jgv.0.001634 PMC 바로가기 [Article Type] Reviews
ORF10–Cullin-2–ZYG11B complex is not required for SARS-CoV-2 infection
423
Published on
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID-19, MERS, SARS,
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID-19, MERS, SARS,
[키워드] acute respiratory syndrome
Antiviral
bind
cellular
complex
coronavirus
coronavirus
Critical
CUL2
cultured cells
Degradation
E3 ubiquitin ligase
Evidence
example
function
gene product
imperative
in vitro
Infection
inhibit
inhibitor
Interaction
investigated
N terminus
ORF10
Pathogenesis
promote
proteasomal degradation
Protein
protein-coding gene
regulate
regulated
required
SARS-CoV-2
SARS-COV-2 infection
Significance
subsequent
the SARS-CoV-2 genome
Transmission
understanding
unique
viral genome
virulence
while
ZER1
ZYG11B
[DOI] 10.1073/pnas.2023157118 PMC 바로가기 [Article Type] 423
[DOI] 10.1073/pnas.2023157118 PMC 바로가기 [Article Type] 423
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors
Research Article
[키워드] addition
anticancer
antiviral activity
antiviral drug
approved drugs
assays
binding
binding site
clinical trials
complex
Compound
compounds
COVID-19 outbreak
COVID-19 treatments
crystal structure
drug
drug candidate
Drug repurposing
effective
Efficacy
enzyme
functional
gene product
identify
inhibit SARS-CoV-2
inhibitor
interferon stimulating gene product 15
ISG15
M pro
motif
New coronavirus
Papain-like protease
PLPro
protease
responsible
SARS-CoV-2
screened
supplementary material
target
the interferon
the SARS-CoV-2
Treatment
unique
viral replicase polyprotein
YM155
[DOI] 10.1007/s13238-021-00836-9 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1007/s13238-021-00836-9 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia
Immunology
[키워드] addition
Anomaly
association
axis
bystander
catastrophic
CNS
COVID-19
COVID-19 case
declining
deubiquitinase
distress
downstream
dysfunction
Exosome
Exosomes
explain
expression
gene product
Host
Host immune response
Human
Hyperactivation
IFN-β
immune cascade
IRF9
knowledge
microglia
microRNA
modify
mRNA
nervous
Neuroinflammation
neurological
NF-κB
Novel coronavirus infection
organ
pathway
patients
pro-inflammatory gene expression
Protein
provide
regulate
Replication
SARS-CoV-2
shown
Specific
spike
spike gene
supported
suppress
syndrome
System
target
target gene
tissue
TNFα
transfected cell
transported
ubiquitin
uninfected
USP33
Vaccine
Viral load
virus
[DOI] 10.3389/fimmu.2021.656700 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2021.656700 PMC 바로가기 [Article Type] Immunology
Base Composition and Host Adaptation of the SARS-CoV-2: Insight From the Codon Usage Perspective
Microbiology
[키워드] acute respiratory syndrome
adaptation
adaptive
Analysis
avoidance
base
base composition
Clinical severity
coding sequences
codon
codon adaptation index
codon pair usage
codon usage
complex interplay
coronavirus
CpG
dinucleotide
event
Factor
gene product
Host
host adaptation
hosts
human host
human immune response
human populations
information
insight
MERS
Middle East
multivariate
natural selection
progression
raised
Research
robust
SARS-CoV
SARS-CoV-2
statistical analysis
syndrome
Transmission dynamics
Usage
Vaccine
viral isolate
virus
[DOI] 10.3389/fmicb.2021.548275 PMC 바로가기 [Article Type] Microbiology
[DOI] 10.3389/fmicb.2021.548275 PMC 바로가기 [Article Type] Microbiology
OmicLoupe: facilitating biological discovery by interactive exploration of multiple omic datasets and statistical comparisons
Software
[키워드] analyses
analysis
Analysis
change
comparison
correlation
dataset
demonstrated
example
expand
expected
Explorative analysis
expression
facilitate
facilitated
Features
gene product
interactive
limitation
multiomics
overlap
protein levels
provide
Quality control
Result
RShiny
SARS-COV-2 infection
selected
statistical
Still
transcript
Visual
Visualization
[DOI] 10.1186/s12859-021-04043-5 PMC 바로가기 [Article Type] Software
[DOI] 10.1186/s12859-021-04043-5 PMC 바로가기 [Article Type] Software